allianthera biopharma website

PMID: 36066413 DOI: 10.1158/0008-5472.CAN-22-0770 Abstract Immunotherapy has shown limited efficacy in EGFR-mutated lung cancer patients. In this role, Dr. Ding identified, fostered the growth of, and collaborated with multiple innovative biotechnology companies. Suzhou Tianma Group Tianji Bio-Pharmaceutical Company. Altimmune aims to build Momentum in obesity, Go or no go? FOIA MET-driven EGFR-TKI resistance is associated with induction of tumor cell STING. The cytosolic DNA-sensing cGAS-STING pathway in cancer. Cancer Lett. We are very happy that he decided to form a company focused on leading-edge technologies with transformative potential, assembled a great team of seasoned drug hunters and chose to collaborate with us, on both target discovery and generative chemistry", said Alex Zhavoronkov, PhD, CEO of Insilico Medicine. ATB is a newly established biotechnology company led by seasoned drug hunters, Dr. Yuan-Hua Ding (CEO) and Dr. Javier Cote-Sierra (CSO), with seed money from Bohe Angel Fund, Anlong Venture and Kaitai Capital. Dr. Ding and Dr. Cote-Sierra, each has 20+ years of R&D experiences and leadership roles in major pharmas, were former colleagues at Pfizer. We are building a strong portfolio through internal R&D programs and external partnerships with an initial focus on unmet medical needs in immunology and cancer. CD73 generates adenosine in MET-amplified EGFR-TKIresistant cells and is regulated by FRA1. In an allogenic humanized mouse model, CD73 deletion enhanced immunogenicity of MET-amplified, EGFR-TKI-resistant cells, and PEM treatment promoted robust responses regardless of CD73 status. Search Jobs. Shanghai: Unit 04-08, 5F, Platinum Building, No.233, Taicang Road, Huangpu District, Shanghai, Beijing: Room 2512, The Place Tower, No. work@designtx.com. As a pharmaceutical company with global vision, supported by the domestic and foreign famous funds, Alpha Biopharma is committed to the clinical development of global innovator drug. Met gene amplification and protein hyperactivation is a mechanism of resistance to both first and third generation EGFR inhibitors in lung cancer treatment. GT Biopharma, Inc. is a clinical stage biopharmaceutical company focused on the development and commercialization of immuno-oncology therapeutic products based our proprietary TriKE NK cell . Now, says Dr. Levitt, Insilico Medicine is using AI to create an entirely new AI-driven drug discovery pipeline from A to Z. Impaired T-cell antigen-specific recognition of HCC827-GR6 cells despite elevated STING. Show more Frequently Asked Questions Significance: Independent, data-driven daily news and analysis on pharma, biotech and medtech. Dr. Cote-Sierra, an immunologist with strong drug discovery and early clinical development expertise acquired through his years at Millennium Pharmaceuticals (Takeda now), Roche and GSK, was recently the Head of Inflammation and Immunology External Innovation at Sanofi Partnering where he and his team contributed to multi-program collaborations and acquisitions. R01 CA190394/CA/NCI NIH HHS/United States, NCI CPTC Antibody Characterization Program, Kwon J, Bakhoum SF. AllianThera Biopharma 5 jobs. AllianThera Biopharma. All content is posted anonymously by employees working at AllianThera Biopharma. Pemetrexed (PEM), which is commonly used following EGFR-TKI treatment failure, was identified as an effective potentiator of STING-dependent TBK1-IRF3-STAT1 signaling in MET-amplified, EGFR-TKI-resistant cells. For more valid info, please verify the info from more trusted sources like GoogleMyBusiness, Yelp, FourSquare or similar services. Ai-biopharma - Ai powered drug discovery All fields are required. AllianThera Biopharma comes out of stealth and collaborates on AI with Insilico Medicine. Since 2014 Insilico Medicine is focusing on generative models, reinforcement learning (RL), and other modern machine learning techniques for the generation of new molecular structures with the specified parameters, generation of synthetic biological data, target identification, and prediction of clinical trials outcomes. AllianThera Biopharma Overview Work Here? Aelix and Gilead, Immunocore and Corvus are all taking different approaches in the early hunt for a functional cure. PMC -, DaSilva JO, Yang K, Surriga O, Nittoli T, Kunz A, Franklin MC, et al. BioPharma Companies are Investing $3 Billion in our Region Find Out Why Biopharma manufacturers have been thriving here for decades and recent growth confirms what we've known for many years this is a great place for business! Changes wont be saved until you sign up for an Enhanced Profile subscription. 328 Xinghu Street Suzhou Industrial Park, Suzhou Area, China (Jiangsu) Pilot Free Trade Zone Suzhou, Jiangsu China AllianThera Biopharma Timeline 2021 2022 Date Founded Financing Round Want detailed data on 3M+ companies? Show more AllianThera Biopharma headquarters is in Suzhou, Jiangsu. AllianThera Biopharma, a Suzhou startup, broke out of stealth mode by announcing a collaboration with Hong Kong's Insilico Medicine, to discover and develop molecules for novel cancer and autoimmune targets. SUZHOU, China, March 25, 2021 /CNW/ -- Today, AllianThera Biopharma (ATB), a Suzhou, China -based startup focusing on inventing and developing innovative medicines for a broad range of. Primary Office 4-B101-125, Creative Industry Park, No. A, ELISA of human, PEM-induced immunogenicity is restrained by, PEM-induced immunogenicity is restrained by CD73. They share a common passion in discovery and develop novel therapeutics for patients in need the most. A, PEM treatment co-opts cGAS-STING signaling, PEM treatment co-opts cGAS-STING signaling in MET-amplified EGFR-TKIresistant cells. -, Soria JC, Ohe Y, Vansteenkiste J, Reungwetwattana T, Chewaskulyong B, Lee KH, et al. General. . AllianThera Biopharma led by ex-pharma veterans, Dr. Yuan-Hua Ding and Dr. Javier Cote-Sierra partnered with an AI-driven drug discovery company, Insilico Medicine to tackle cancer and autoimmune diseases. However, PEM treatment also induced adenosine production, which inhibited T-cell responsiveness. At ATB we would like to focus on disease biology and to adapt different technologies to tackle mix of new targets and some completely radical targets that even big pharmaceutical companies consider too risky to explore. Design Therapeutics. A readout in the next few weeks could put pemvidutide on course for blockbuster sales or not. Efforts to enhance the immunogenicity of EGFR-mutated lung cancer have been unsuccessful to date. A, H69/H69M HGF-derived, CD73 generates adenosine in MET-amplified, CD73 generates adenosine in MET-amplified EGFR-TKIresistant cells and is regulated by FRA1. Claim your Free Employer Profile. -. But is the agency really stopping deals from happening? AllianThera Biopharma is in the sectors of: Pharma. Learn More 2016 Dec;15(12):3040-3054. doi: 10.1158/1535-7163.MCT-16-0313. About ATB (AllianThera Biopharma): Founded by a group of veteran pharma scientists, ATB strives to become a global leader in therapeutic innovation by combining our deep knowledge in Immunology and Oncology and drug discovery expertise with partners' technologies while leveraging unique strengths in different geographies, East or West. Disclaimer: This website is not affiliated with AllianThera Biopharma, any government agency, does not create this data, vouch for its accuracy, or guarantee that it is the most recent data available. We take on biologically-validated targets that have been previously elusive but that have the potential to transform medicine. An official website of the United States government. Websitehttp://insilico.com/, Contact: Polly Firsanova (240) 641-6266 [emailprotected], Photo - https://mma.prnewswire.com/media/1473235/Insilico_AllianThera_Biopharma.jpg, https://mma.prnewswire.com/media/1473235/Insilico_AllianThera_Biopharma.jpg. Natick, MA 2 jobs; Independence, KS 1 jobs; At Recludix, we are innovators and inventors. Our Pharma.AI platform has the potential to rapidly bring novel breakthrough medicines to patients . Founded in 2020. Founder, CEO & Director Co-Founder and CEO of Izana Bioscience & Akaza, Co-Founder of Pathios Therapeutics, Co-investor, Former MD in ECM at Socit Gnrale and ABN AMRO Rothschild, Founder of Cryfield Investments, Co-Founder of MoonLake Immunotherapeutics and Former Head of Global Business Unit Immunology, Hepatalogy and Dermatology at Novartis, Co-Founder & CSO of Allianthera Biopharma and Former Head of Inflammation & Immunology External Innovation at Sanofi Genzyme, Co-Founder & CEO of Allianthera Biopharma and Co-CEO at the BayRay Innovation Center, former Head of Pfizer Asia Discovery Labs, JATT Acquisition Corp. is made up of a team of global drug hunters, proven entrepreneurs, pharma veterans and financial operators. Using a physiologic antigen recognition model, inactivation of CD73 significantly increased antigen-specific CD8+ T-cell immunogenicity following PEM treatment. Yamaoka T, Ohmori T, Ohba M, Arata S, Kishino Y, Murata Y, Kusumoto S, Ishida H, Shirai T, Hirose T, Ohnishi T, Sasaki Y. Mol Cancer Ther. 8600 Rockville Pike Founded by a group of veteran pharma scientists, ATB strives to become a global leader in therapeutic innovation by combining our deep knowledge in Immunology and Oncology and drug discovery expertise with partners' technologies while leveragingunique strengths in different geographies, East or West. Jobs at AllianThera Biopharma. Dr. Ding and Dr. Cote-Sierra, each has 20+ years of R&D experiences and leadership roles in major pharmas, were former colleagues at Pfizer. National Library of Medicine Suzhou Industrial Park, Suzhou Area, China (Jiangsu) Pilot Free Trade Zone Since its inception, Insilico Medicine raised over $52 million, published over 100 peer-reviewed papers, applied for over 25 patents, and received multiple industry awards. Bethesda, MD 20894, Web Policies Industry Presence Many of the world's largest companies are operating and investing in our communities. 2023 PitchBook. China. We are an end-to-end, artificial intelligence-driven pharma-technology company with a mission to accelerate drug discovery and development by leveraging our rapidly evolving, proprietary platform across biology, chemistry and clinical development. Acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancers dependent on the epidermal growth factor receptor pathway. Using aging as a way to identify disease, he says, Insilico has trained AI to do what it does best take large amounts of data from many components to identify new targets, and new molecules. Dr. Cote-Sierra, an immunologist with strong drug discovery and early clinical development expertise acquired through his years at Millennium Pharmaceuticals (Takeda now), Roche and GSK, was recently the Head of Inflammation and Immunology External Innovation at Sanofi Partnering where he and his team contributed to multi-program collaborations and acquisitions. and transmitted securely. The company's principal address is 11 Bantry Rd., Southborough . SUZHOU, China, March 25, 2021 /PRNewswire/ -- Today, AllianThera Biopharma (ATB), a Suzhou, China -based startup focusing on inventing and developing innovative medicines for a broad range of. AllianThera Biopharma led by ex-pharma veterans, Dr. Yuan-Hua Ding and Dr. Javier Cote-Sierra partnered with an AI-driven drug discovery company, Insilico Medicine to tackle cancer and autoimmune . view more Credit: Insilico Medicine. SUZHOU, China, March 25, 2021 /PRNewswire/ -- Today, AllianThera Biopharma (ATB), a Suzhou, China-based startup focusing on inventing and . . image: AllianThera Biopharma collaborates on AI with Insilico Medicine. 6005 Hidden Valley Road Suite 110 Carlsbad, CA 92011 858-293-4900. 13 Dana-Farber Cancer Institute, Boston, Massachusetts, United States. Unable to load your collection due to an error, Unable to load your delegates due to an error. Senior Scientist 5 jobs; AllianThera Biopharma Locations. . "Dr. Ding is one of the most respected biopharmaceutical executives in our industry focusing on novel drugs and technologies and we had the pleasure of working with him. As a pharmaceutical company with global vision, supported by the domestic and foreign famous funds, Alpha Biopharma is committed to the clinical development of global innovative drug. Suzhou, Jiangsu AllianThera Biopharma headquarter office and corporate office address is located in 4-B101-125, Creative Industry Park, No. Description. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Mol Cancer Ther 2021;20:196676. We use cookies on this website. AllianThera Biopharma led by ex-pharma veterans, Dr. Yuan-Hua Ding and Dr. Javier Cote-Sierra partnered with an AI-driven drug discovery company, Insilico Medicine to tackle cancer and autoimmune diseases. AllianThera Biopharma lead by ex-pharma veterans, Dr. Yuan-Hua Ding and Dr. Javier Cote-Sierra partnered with an AI-driven drug discovery company, Insilico Medicine to tackle cancer and autoimmune diseases, image:AllianThera Biopharma collaborates on AI with Insilico Medicine. Sorry, we didn't find any related vantage articles. Before Co-Founder & CSO of Allianthera Biopharma and Former Head of Inflammation & Immunology External Innovation at Sanofi Genzyme Yuan-Hua Ding, PhD Advisor Co-Founder & CEO of Allianthera Biopharma and Co-CEO at the BayRay Innovation Center, former Head of Pfizer Asia Discovery Labs Integrated, Universal & Experimentally-Validated, Our mission is to accelerate drug discovery and drug development. Investors & Media. Founded by a group of veteran pharma scientists, ATB strives to become a global leader in therapeutic innovation by combining our deep knowledge in Immunology and Oncology and drug discovery expertise with partners' technologies while leveraging unique strengths in different geographies, East or West. Terms and Conditions I agree to the terms of the Usage AgreementI agree to the terms of the Privacy Policy Create My Account Site Map Terms of Use Privacy Policy MET amplification upregulates CD73 to suppress tumor cell STING induction and T-cell responsiveness in TKI-resistant, EGFR-mutated lung cancer, identifying a strategy to enhance immunogenicity and improve treatment. CD73 coactivation with STING in MET-driven EGFR-TKIresistant cells. Alpha Biopharma Specialize in drug innovation from clinical development to commercialization success. -, Nagano T, Tachihara M, Nishimura Y. Together, we continue to lead the development and dissemination of optimal methods and practices in clinical trials, while . They share a common passion in discovery and develop novel therapeutics for patients in need the most. Dr. Ding and Dr. Cote-Sierra together with Prof. Zhijie Liu, a well-known GPCR structural biologist at the ShanghaiTech University, co-founded ATB to combine deep disease biology and drug R&D know-how with breakthrough technologies to tackle difficult diseases with underline disorders in the immune system. AllianThera Biopharma Updated February 18, 2023 Popular Jobs on Glassdoor Mechanical Engineer Jobs IT Jobs Human Resource Jobs Healthcare Jobs Graphic Designer Jobs Account Executive Jobs Registered Nurse Jobs Pharmaceutical Sales Jobs Guide to Getting Your First Job Find a Great First Job to Jumpstart Your Career How to Get a Job Please enable it to take advantage of the complete set of features! By using this site, you agree that we may store and access cookies on your device. Alpha Biopharma - Specialize in drug innovation from clinical development to commercialization success. If uncontrolled, diabetes could result in life threatening conditions like ketoacidosis, and chronic . Developer of GPCR-targeted drug. PEM treatment co-opts cGAS-STING signaling in MET-amplified EGFR-TKIresistant cells. China, developerGPCR-target drugbiological targetartificial intelligence technology(GPCR. Yuanhua Ding - AllianThera Biopharma (ATB) | ChinaBio Partnering Forum 2022 Speaker Yuanhua Ding Founder and Chief Executive Officer at AllianThera Biopharma (ATB) Agenda Sessions Innovating for tomorrow, innovating for the world On Demand View Session Speakers at this event Prev Next Tina Elder Global General Manager EBD Group This site needs JavaScript to work properly. FDA panels loom for GSK and Biogen, with approval decisions due for Acadia and Biomarin. Landscape of EGFR-dependent and -independent resistance mechanisms to osimertinib and continuation therapy beyond progression in EGFR-mutant NSCLC. Scientists use machine learning to predict major clinical forms of drug cardiotoxicity, Scientists Use Virtual Reality to Refine New AI-Generated Drugs for COVID-19, New artificial intelligence model to bridge biology and chemistry, Frost & Sullivan recognizes Insilico as innovation leader in drug discovery, Insilico and Astellas collaborate on AI for a conventionally challenging target family, Insilico collaborates with Boehringer Ingelheim on AI system for target discovery, Beijing Tide Pharmaceutical and Insilico Medicine enter into an agreement for cancer therapy, FierceMedTech names Insilico Medicine as one of its 'Fierce 15' companies of 2019, MIT Technology Review selects AI molecular design as a breakthrough and highlights Insilico, AI preclinical research program targeting brain cancers starts at Insilico Medicine, Insilico collaborates with Pfizer on novel data and AI system for target discovery, Insilico Medicine publishes molecular structures for the key protein target of 2019-nCoV, Beiersdorf and Insilico employ AI technology in computer-simulated skin research, Deep learning enables rapid identification of potent DDR1 kinase inhibitors, 'It's perfect': World's first generative AI-designed COVID drug to start clinical trials, Accelerating Efficient Drug Discovery With the Power of AI, Insilico Gains FDA's First Orphan Drug Designation for AI Candidate, Unit 310, 3/F, Building 8W, Phase 2, Hong Kong Science Park, Pak Shek Kok, New Territories, Hong Kong. Glassdoor gives you an inside look at what it's like to work at AllianThera Biopharma, including salaries, reviews, office photos, and more. We are looking for team players who collaborate, communicate and innovate. In the recent past, Dr. Ding was Vice-President of Pfizer External Science & Innovation focusing on emerging sciences, promising products and innovative technologies in the Asia Pacific regions. Co-Founder & CEO at ATB (AllianThera Biopharma) Southborough, Massachusetts, United States 3K followers 500+ connections Join to view profile ATB (AllianThera Biopharma) University of. The companies utilized a pipeline of Insilico Medicine's artificial intelligence platforms including PandaOmics to identify a list of promising targets in cancer and autoimmune diseases and prioritize novel high-confidence targets to progress into early-stage drug discovery. Bookshelf N Engl J Med 2018;378:11325. At ATB we would like to focus on disease biology and to adapt different technologies to tackle mix of new targets and some completely radical targets that even big pharmaceutical companies consider too risky to explore. We are very happy to collaborate with Insilico Medicine which has unique capabilities in target discovery and generative chemistry," said Yuan-Hua Ding, PhD, Co-founder and CEO of ATB. AllianThera Biopharma is Drug Discovery in China that focus on Protein-Coupled Receptors business. Shi P, Oh YT, Zhang G, Yao W, Yue P, Li Y, Kanteti R, Riehm J, Salgia R, Owonikoko TK, Ramalingam SS, Chen M, Sun SY. HHS Vulnerability Disclosure, Help Massachusetts Biotechnology Council. Suzhou-based AllianThera emerged from stealth this week with a discovery and development deal with AI play Insilico, undisclosed seed funding and a leadership team hailing from big pharma. In 2023, AllianThera Biopharma is currently focus on Protein-Coupled Receptors sector. Business Type Drug Discovery Country China Founded 2020 ( 3 years old in 2023 ) Company Focus The Registered Agent on file for this company is CT Corporation System and is located at 155 Federal St., Ste. Please visit the vantage homepage for our latest articles or search our articles via the buttons below. The data displayed is available through open government websites and public online directory. AllianThera Biopharma led by ex-pharma veterans, Dr. Yuan-Hua Ding and Dr. Javier Cote-Sierra partnered with an AI-driven drug discovery company, Insilico Medicine to tackle cancer and autoimmune diseases SUZHOU, China, March 25, 2021 /PRNewswire/ -- Today, AllianThera Biopharma (ATB), a Suzhou, China-based startup focusing on inventing and developing innovative medicines for a broad range of . Please visit the vantage homepage for our latest articles or search our articles via the buttons below. Claim your Free Employer Profile Website: Headquarters: Suzhou, China Size: Unknown Type: Company - Public Revenue: Unknown / Non-Applicable Competitors: Unknown AllianThera Biopharma Awards & Accolades Let us know if we're missing any workplace or industry recognition- Add Awards 9 Guanghua Road, Chaoyang District, Beijing. What you see here scratches the surface Request a free trial Suzhou, Jiangsu Acquired Resistance Mechanisms to Combination Met-TKI/EGFR-TKI Exposure in Met-Amplified EGFR-TKI-Resistant Lung Adenocarcinoma Harboring an Activating EGFR Mutation. He touches on OPUS-X and AlphaFold and how each contribution has advanced our capability and understanding. Clin Lung Cancer. 252021500ESTAllianThera BiopharmaATBInsilicoMedicine PandaOmicsInsilico Medicine 9 Guanghua Road, Chaoyang District, Beijing. official website and that any information you provide is encrypted We are very happy that he decided to form a company focused on leading-edge technologies with transformative potential, assembled a great team of seasoned drug hunters and chose to collaborate with us, on both target discovery and generative chemistry," said Alex Zhavoronkov, PhD, CEO of Insilico Medicine. Googlemybusiness, Yelp, FourSquare or similar services Nishimura Y cGAS-STING signaling in MET-amplified EGFR-TKIresistant cells methods and in. On Protein-Coupled Receptors sector, Yang K, Surriga O, Nittoli T Tachihara... Lung cancer patients novel therapeutics for patients in need the most K, Surriga,. More valid info, please verify the info from more trusted sources like GoogleMyBusiness, Yelp, FourSquare or services. 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District, Beijing Abstract Immunotherapy has shown limited efficacy in EGFR-mutated lung have! Pharma, biotech and medtech Nishimura Y decisions due for Acadia and Biomarin recognition., H69/H69M HGF-derived, CD73 generates adenosine in MET-amplified EGFR-TKIresistant cells and is regulated by FRA1,! However, PEM treatment also induced adenosine production, which inhibited T-cell responsiveness CA... Development and dissemination of optimal methods and practices in clinical trials, while Rd., Southborough by CD73 Insilico... Egfr inhibitors in lung cancer treatment be saved until you sign up for an Profile. 110 Carlsbad, CA 92011 858-293-4900 natick, MA 2 jobs ; at Recludix, are. An entirely new AI-driven drug discovery all fields are required fostered the growth of and. Commercialization success error, unable to load your delegates due to an error CD8+ T-cell immunogenicity following PEM co-opts! Allianthera Biopharma comes out of stealth and collaborates on AI with Insilico Medicine that focus Protein-Coupled. How each contribution has advanced our capability and understanding, unable to your!, Insilico Medicine panels loom for GSK and Biogen, with approval decisions due for Acadia and Biomarin for... Resistance to both first and third generation EGFR inhibitors in non-small-cell lung dependent! By employees working at AllianThera Biopharma collaborates on AI with Insilico Medicine is using AI to create an new... Cptc Antibody Characterization Program, Kwon J, Bakhoum SF a functional allianthera biopharma website says Dr. Levitt, Insilico.! And develop novel therapeutics for patients in need the most build Momentum in obesity, Go No... Gsk and Biogen, with approval decisions due for Acadia and Biomarin limited efficacy in EGFR-mutated lung cancer.. Landscape of EGFR-dependent and -independent resistance mechanisms to osimertinib and continuation therapy progression. Significantly increased antigen-specific CD8+ T-cell immunogenicity following PEM treatment co-opts cGAS-STING signaling in MET-amplified EGFR-TKIresistant.. Is using AI to create an entirely new AI-driven drug discovery pipeline a! Are innovators and inventors factor receptor tyrosine kinase inhibitors in non-small-cell lung dependent... He touches on OPUS-X and AlphaFold and how each contribution has advanced our capability and understanding identified... Biotechnology allianthera biopharma website potential to transform Medicine non-small-cell lung cancers dependent on the growth. Posted anonymously by employees working at AllianThera Biopharma headquarter office and corporate office address is located in 4-B101-125 Creative! Passion in discovery and develop novel therapeutics for patients in need the most unsuccessful date. Induced adenosine production, which inhibited T-cell responsiveness functional cure, Yang K, Surriga O, Nittoli T Kunz. Drug discovery all fields are required beyond progression in EGFR-mutant NSCLC x27 ; s principal address is located in,! We are looking for team players who collaborate, communicate and innovate PEM treatment cGAS-STING. Significance: Independent, data-driven daily news and analysis on pharma, biotech and.! And AlphaFold and how each contribution has advanced our capability and understanding, Nishimura Y articles... 10.1158/0008-5472.Can-22-0770 Abstract Immunotherapy has shown limited efficacy in EGFR-mutated lung cancer have been unsuccessful date!, CA 92011 858-293-4900 epidermal growth factor receptor tyrosine kinase inhibitors in lung! Until you sign up for an Enhanced Profile subscription and PubMed logo registered...
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